Life cycle of cytosolic prions
نویسندگان
چکیده
منابع مشابه
Life cycle of cytosolic prions
Prions are self-templating protein aggregates that were originally identified as the causative agent of prion diseases in mammals, but have since been discovered in other kingdoms. Mammalian prions represent a unique class of infectious agents that are composed of misfolded prion protein. Prion proteins usually exist as soluble proteins but can refold and assemble into highly ordered, self-prop...
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15 صفحه اولPrions.
The discovery of infectious proteins, denoted prions, was unexpected. After much debate over the chemical basis of heredity, resolution of this issue began with the discovery that DNA, not protein, from pneumococcus was capable of genetically transforming bacteria (Avery et al. 1944). Four decades later, the discovery that a protein could mimic viral and bacterial pathogens with respect to the ...
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ژورنال
عنوان ژورنال: Prion
سال: 2013
ISSN: 1933-6896,1933-690X
DOI: 10.4161/pri.26414